%
% Neuronal Calcium Sensors Subfamily
% ==================================
%
% http://structbio.vanderbilt.edu/cabp_database/seq/align/ncsfam.aln.html
%
% This example was taken from the CaBP database with the kind permission 
% of Walter Chazin (Center for Structural Biology, Vanderbilt University).
% It is out of date and should not be used for other than demo purposes.
%
% Key: * = perfect match; : = high similarity; . = low similarity
%

"NCS1_RAT"      --GKSNSKLKPEVVEELTRKTYFTEKEVQQWYKGFIKDCPSGQLDAAGFQKIYKQFFPFG
"NCS1_XENLA"    --GKSNSKLKPEVVEELTRKTYFTEKEVQQWYKGFIKDCPSGQLDATGFQKIYKQFFPFG
"NCS1_CAEEL"    --GKGNSKLKSSQIRDLAEQTYFTEKEIKQWYKGFVRDCPNGMLTEAGFQKIYKQFFPQG
"FREQ_DROME"    --GKKSSKLKQDTIDRLTTDTYFTEKEIRQWHKGFLKDCPNGLLTEQGFIKIYKQFFPQG
"NCS1_YEAST"    --GAKTSKLSKDDLTCLKQSTYFDRREIQQWHKGFLRDCPSGQLAREDFVKIYKQFFPFG
"VIS3_HUMAN"    --GKQNSKLRPEVLQDLREKTEFTDHELQEWYKGFLKDCPTGHLTVDEFKKIYANFFPYG
"VIS3_RAT"      --GKQNSKLRPEVLQDLREHTEFTDHELQEWYKGFLKDCPTGHLTVDEFKKIYANFFPYG
"VIS3_CHICK"    --GKQNSKLRPEVLQDLRENTEFTDHELQEWYKGFLKDCPTGHLTVEEFKKIYANFFPYG
"HIPP_HUMAN"    --GKQNSKLRPEMLQDLRENTEFSELELQEWYKGFLKDCPTGILNVDEFKKIYANFFPYG
"HIPP_RAT"      --GKQNSKLRPEMLQDLRENTEFSELELQEWYKGFLKDCPTGILNVDEFKKIYANFFPYG
"VIS1_HUMAN"    --GKQNSKLAPEVMEDLVKSTEFNEHELKQWYKGFLKDCPSGRLNLEEFQQLYVKFFPYG
"VIS1_RAT"      --GKQNSKLAPEVMEDLVKSTEFNEHELKQWYKGFLKDCPSGRLNLEEFQQLYVKFFPYG
"VIS2_RAT"      --GKNNSKLAPEELEDLVQNTEFSEQELKQWYKGFLKDCPSGILNLEEFQQLYIKFFPYG
"NCS2_CAEEL"    GIKGSKPKLSKEDLEFLKKNTNFTEEQIKEWYKGFVQDCPKGHLTKEQFIKVYKDFFPSG
"RECO_BOVIN"    -GNSKSGALSKEILEELQLNTKFTEEELSSWYQSFLKECPSGRITRQEFQTIYSKFFPEA
"RECO_MOUSE"    -GNSKSGALSKEILEELQLNTKFTEEELSAWYQSFLKECPSGRITRQEFESIYSKFFPDS
"RECO_HUMAN"    -GNSKSGALSKEILEELQLNTKFSEEELCSWYQSFLKDCPTGRITQQQFQSIYAKFFPDT
"SMOD_RANCA"    -GNTKSGALSKEILEELQLNTKFTQEELCTWYQSFLKECPSGRISKKQFESIYSKFFPDA
"VISI_CHICK"    -GNSRSSALSREVLQELRASTRYTEEELSRWYEGFQRQCPDGRIRCDEFERIYGNFFPNS
%                    .  *  . :  *   * :   ::  *::.* ::** * :    *  :* .***  

"NCS1_RAT"      DPTKFATFVFNVFDENKDGRIEFSEFIQALSVTSRGTLDEKLRWAFKLYDLDNDGYITRN
"NCS1_XENLA"    DPTKFATFVFNVFDENKDGRIEFSEFIQALSVTSRGTLDEKLRWAFKLYDLDNDGYITRN
"NCS1_CAEEL"    DPSDFASFVFKVFDENKDGAIEFHEFIRALSITSRGNLDEKLHWAFKLYDLDQDGFITRN
"FREQ_DROME"    DPSKFASLVFRVFDENNDGSIEFEEFIRALSVTSKGNLDEKLQWAFRLYDVDNDGYITRE
"NCS1_YEAST"    SPEDFANHLFTVFDKDNNGFIHFEEFITVLSTTSRGTLEEKLSWAFELYDLNHDGYITFD
"VIS3_HUMAN"    DASKFAEHVFRTFDTNGDGTIDFREFIIGLSVTRGGKLEQKLKWAFSMYDLDGNGYISRS
"VIS3_RAT"      DASKFAEHVFRTFDTNSDGTIDFREFIIALSVTSRGKLEQKLKWAFSMYDLDGNGYISRS
"VIS3_CHICK"    DASKFAEHVFRTFDTNGDGTIDFREFIIALSVTSRGKLEQKLKWAFSMYDLDGNGYISRG
"HIPP_HUMAN"    DASKFAEHVFRTFDTNSDGTIDFREFIIALSVTSPGRLEQKLMWAFSMYDLDGNGYISRE
"HIPP_RAT"      DASKFAEHVFRTFDTNSDGTIDFREFIIALSVTSRGRLEQKLMWAFSMYDLDGNGYISRE
"VIS1_HUMAN"    DASKFGQHAFRTFDKIGDGTIDFREFICALSITSRGXFEQKLNWAFNMYDLDGDGKITXX
"VIS1_RAT"      DASKFAQHAFRTFDKNGDGTIDFREFICALSITSRGSFEQKLNWAFNMYDLDGDGKITRV
"VIS2_RAT"      DASKFAQHAFRTFDKNGDGTIDFREFICALSVTSRGSFEQKLNWAFEMYDLDGDGRITRL
"NCS2_CAEEL"    SAEGFCEHVFRTFDTDNSGFIDFKEFLLAINVTSSGTPEQKLEWAFRMYDIDGNGTIDEK
"RECO_BOVIN"    DPKAYAQHVFRSFDANSDGTLDFKEYVIALHMTSAGKTNQKLEWAFSLYDVDGNGTISKN
"RECO_MOUSE"    DPKAYAQHVFRSFDANSDGTLDFKEYVIALHMTTAGKPTQKLEWAFSLYDVDGNGTISKN
"RECO_HUMAN"    DPKAYAQHVFRSFDSNLDGTLDFKEYVIALHMTTAGKTNQKLEWAFSLYDVDGNGTISKN
"SMOD_RANCA"    DPKAYAQHVFRSFDANNDGTLDFKEYMIALMMTSSGKANQKLEWAFCLYDVDGNGTINKK
"VISI_CHICK"    EPQGYARHVFRSFDTNDDGTLDFREYIIALHLTSSGKTHLKLEWAFSLFDVDRNGEVSKS
%               ..  :    *  **   .* :.* *::  :  *  *    ** *** ::*:: :* :   

"NCS1_RAT"      EMLDIVDAIYQMVGNT--VELPEEENTPEKRVDRIFAMMDKNADGKLTLQEFQEGSKADP
"NCS1_XENLA"    EMLDIVDAIYQMVGNT--VELPEEENTPEKRVDRIFAMMDKNSDGKLTLQEFQEGSKADP
"NCS1_CAEEL"    EMLSIVDSIYKMVGSS--VQLPEEENTPEKRVDRIFRMMDKNNDAQLTLEEFKEGAKADP
"FREQ_DROME"    EMYNIVDAIYQMVGQQ--PQ-SEDENTPQKRVDKIFDQMDKNHDGKLTLEEFREGSKADP
"NCS1_YEAST"    EMLTIVASVYKMMGSM--VTLNEDEATPEMRVKKIFKLMDKNEDGYITLDEFREGSKVDP
"VIS3_HUMAN"    EMLEIVQAIYKMVSSV--MKMPEDESTPEKRTDKIFRQMDTNNDGKLSLEEFIRGAKSDP
"VIS3_RAT"      EMLEIVQAIYKMVSSV--MKMPEDESTPEKRTDKIFRQMDTNNDGKLSLEEFIKGAKSDP
"VIS3_CHICK"    EMLEIVQAIYKMVSSV--MKMPEDESTPEKRTDKIFRQMDTNNDGKLSLEEFIKGAKSDP
"HIPP_HUMAN"    EMLEIVQAIYKMVSSV--MKMPEDESTPEKRTEKIFRQMDTNNDGKLSLEEFIRGAKSDP
"HIPP_RAT"      EMLEIVQAIYKMVSSV--MKMPEDESTPEKRTEKIFRQMDTNNDGKLSLEEFIRGAKSDP
"VIS1_HUMAN"    EMLEIIEAIYKMVGTVIMMKMNEDGLTPEQRVDKIFSKMDXNKDDQITLGEFREAAKSDP
"VIS1_RAT"      EMLEIIEAIYKMVGTVIMMKMNEDGLTPEQRVDKIFSKMDKNKDDQITLDEFKEAAKSDP
"VIS2_RAT"      EMLEIIEAIYKMVGTVIMMRMNQDGLTPQQRVDKIFKKMDQDKDDQITLEEFKEAAKSDP
"NCS2_CAEEL"    EMIKIIEAIYEMLGPE---VTKSADDSPRKRAKMIFEKMDVNNDKELTLKEFVDGCLADK
"RECO_BOVIN"    EVLEIVTAIFKMISPEDTKHLPEDENTPEKRAEKIWGFFGKKDDDKLTEKEFIEGTLANK
"RECO_MOUSE"    EVLEIVMAIFKMIKPEDVKLLPDDENTPEKRAEKIWAFFGKKEDDKLTEEEFIEGTLANK
"RECO_HUMAN"    EVLEIVMAIFKMITPEDVKLLPDDENTPEKRAEKIWKYFGKNDDDKLTEKEFIEGTLANK
"SMOD_RANCA"    EVLEIITAIFKMINAEDQKHLPEDENTPEKRTNKIWVYFGKKDDDKLTEGEFIQGIVKNK
"VISI_CHICK"    EVLEIITAIFKMIPEEERLQLPEDENSPQKRADKLWAYFNKGENDKIAEGEFIDGVMKND
%               *:  *: ::::*:         .   :*. *.. ::  :.   :  ::  **  .   : 

"NCS1_RAT"      SIVQALSLYDGLV---------
"NCS1_XENLA"    SIVQALSLYDGLV---------
"NCS1_CAEEL"    SIVHALSLYEGLSS--------
"FREQ_DROME"    RIVQALSLGGG-----------
"NCS1_YEAST"    SIIGALNLYDGLI---------
"VIS3_HUMAN"    SIVRLLQCDPSSASQF------
"VIS3_RAT"      SIVRLLQCDPSSASQF------
"VIS3_CHICK"    SIVRLLQCDPSSASQF------
"HIPP_HUMAN"    SIVRLLQCDPSSRSQF------
"HIPP_RAT"      SIVRLLQCDPSSASQF------
"VIS1_HUMAN"    SIVLLLQCDIQK----------
"VIS1_RAT"      SIVLLLQCDIQK----------
"VIS2_RAT"      SIVLLLQCDMQK----------
"NCS2_CAEEL"    ELFQILTNEVKK----------
"RECO_BOVIN"    EILRLIQFEPQKVKEKLKEKKL
"RECO_MOUSE"    EILRLIQFEPQKVKERIKEKKQ
"RECO_HUMAN"    EILRLIQFEPQKVKEKMKNA--
"SMOD_RANCA"    EILRLIQYEPQKVKDKLKEKKH
"VISI_CHICK"    AIMRLIQYEPKK----------
%                :.  :                


